CBD industry has reached far beyond the point where it had once started. Active scientific research with animal studies and clinical trials are transforming the industry; needless to say, that this transformation is good for mankind. The advancement that is getting a lot of attention presently is nano CBD.
Nanotechnology is very popular in medicine, robotics, cosmetics, and a plethora of other areas. One of its latest applications is in the cannabidiol industry. Companies referring to nano CBD as “water-soluble CBD” are normally observed, however, it isn’t correct. CBD is a hydrophobic compound that does not dissolve in water. The smaller size of the molecules just creates an illusion of water solubility. We will discuss the details later.
CBD bioavailability is relevant in the discussions about nano CBD because the technology attempts to improve the bioavailability of cannabidiol products. When compared to macro CBD, nano CBD has a higher bioavailability rate. Bioavailability refers to the rate at which CBD enters our bloodstream on consuming a cannabidiol product. The product type and its method of intake influence its bioavailability. For instance, it has been proven that the average bioavailability of consuming CBD orally is as high as 20%. And the lower average bioavailability rate of 4%. This means that when you take 100 mg CBD orally, not more than 20 mg CBD reaches your bloodstream. Vaping is regarded as one of the highest bioavailable CBD intake methods. About 34% to 46% reach our bloodstream by vaping. Bioavailability values of most other intake methods are in between that of oral CBD and vape CBD.
Regular CBD Or Nano CBD – Which Is Most Effective
CBD is a hydrophobic molecule, meaning that it cannot be dissolved in water. It is also a lyophilic or fat-loving compound. They tend to combine with lipids and fats. We all know that our digestive tract as well as mouth is generally watery. This is a clear indicator of the low bioavailability of CBD. Because there is no way water and CBD are mixing, most of the cannabidiol stays hidden in droplets. The first-pass metabolism is also attributed to the low bioavailability of CBD taken orally. Orally ingestible CBD products are processed by our digestive tract and the CBD in it has to bypass the liver. In the process, a significant percentage of CBD fails to absorb into the bloodstream.
When CBD is broken down into nano-sized particles, they act more or less like dissolved substances even though they aren’t. CBD never loses its hydrophobic nature and the term water-soluble CBD is merely used for marketing purposes. Our body finds it easier to process nano-sized CBD particles than regular-sized particles. Smaller CBD oil droplets have increased contact area with the absorptive tissue and enzymes in our body. Hence there is a better rate of CBD absorption on taking nano CBD. Breaking CBD into nanoparticles does not mean that it will be readily absorbed into the bloodstream. It still requires some processing and is absorbed slower than water-soluble molecules.
Scientific Research And Nano CBD
The research on nano CBD is limited and as of now, all the research results suggest that nano CBD oil increases the percentage of CBD that enters our bloodstream.
A comparison was made between the bioavailability of CBD / THC nanoemulsion with that of Sativex in healthy male volunteers, by a 2018 study published in the Journal Of Pharmaceutical Sciences. The researchers found that the absorption rate of nanoemulsion was higher than that of Sativex. A similar comparison was made and published by a 2017 study published in the Journal of Controlled Release, but it included Piperine in the CBD/THC nanoemulsion. The study showed an increase in the absorption of CBD or THC when compared to Sativex. However, take note of the fact that Piperine, a natural absorption enhancer could also have influenced the results.
Risks Associated With Nano CBD
Although Nano CBD has a promising future, more research is required when it comes to its safety. Due to its small size, the accumulation of nanoparticles in human cells and organs is a possibility. This accumulation could result in inflammation and tissue damage. According to a report by the Organization for Economic Co-operation and Development, it is unclear whether nanoparticles can pass from a pregnant woman to the fetus through the placenta. Even when particle size decreases, CBD particles behave more or less similarly to macro-sized particles. However, once the particles start becoming tinier, up to a few hundred nanometers and less, they begin to show some properties different from that of regular-sized particles. They might pass through some gaps and reach tissues that regular-sized particles would not reach.
The higher absorption rate of nano CBD implies that dosages lower than that used previously would be enough to give the expected results. Users have to be careful about the dosage even though overdosing with CBD is not possible.